Induced Pluripotent Stem Cells Vs Mesenchymal Stem Cells

Induced pluripotent stem cells also known as ips cells or ipscs are a type of pluripotent stem cell that can be generated directly from a somatic cell the ipsc technology was pioneered by shinya yamanaka s lab in kyoto japan who showed in 2006 that the introduction of four specific genes named myc oct3 4 sox2 and klf4 encoding transcription factors could convert somatic cells into.

Induced pluripotent stem cells vs mesenchymal stem cells.

There has been considerable interest in the generation of functional mesenchymal stromal cell msc preparations from induced pluripotent stem cells ipscs and this is now regarded as a potential source of unlimited standardized high quality cells for therapeutic applications in regenerative medicine. Many types of stem cells are being explored for their potential benefits for treating multiple sclerosis. They are classified as either totipotent itc pluripotent ipsc or progenitor multipotent imsc also called an induced multipotent progenitor cell impc or unipotent iusc according to their developmental potential and degree of. In this way an adult somatic cell which is not pluripotent can be converted into the induced pluripotent cell.

Induced stem cells isc are stem cells derived from somatic reproductive pluripotent or other cell types by deliberate epigenetic reprogramming. The key difference between pluripotent and induced pluripotent stem cells is that the pluripotent cells are undifferentiated mother cells from embryos etc which have the natural ability to differentiate into different cell types whereas the induced pluripotent stem cells are somatic adult cells that have been genetically reprogrammed to show characteristics similar to natural pluripotent. Stem cells have excited researchers because of their potential to regenerate. Mesenchymal stem cells are adult stem cells found in several places in the body including the bone marrow skin and fat tissue.

Mesenchymal stem cells msc and induced pluripotent stem cell ipscs derived precursor cells can modulate the autoimmune. Compared to pluripotent stem cells with associated risks of immune rejection and teratoma formation adult stem cells especially the mesenchymal stem cells mscs are hyped to be a suitable alternate since they also. Strikingly most embryonic stem cell and induced pluripotent stem cell applications have the potential to improve human health none more directly so than esc or ipsc therapy. The most intuitive approach for es or ips cell therapy is to transplant psc derived cells for the direct replacement of damaged or degenerated cells or tissue.

Induced pluripotent stem cells ips cells differ from embryonic stem cells es cells which form the inner cell mass of an embryo but also are pluripotent eventually giving rise to all the cell types that. Tremendous progress in the experimental and clinical applications of cell based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including ms. Read about other types of stem cells. This page focuses on research related to mesenchymal stem cells and induced pluripotent stem cells in ms.

However which stem cells will be the best candidate for regenerative medicine remains an enigma.